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  • Deficits of Mesolimic Dopamine Neurotransmission in Rat Dietary Obesity
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Similar to the Johnson and Kenny paper, this article by Geiger et al. places rats on a cafeteria diet to induce obesity. Instead of looking at BSR levels, Geiger et al. measure extracellular dopamine levels in the nucleus accumbens. They also look at dopamine release in the nucleus accumbens upon stimulation by food and after amphetamine administration. Consistent with other research that states that the reward circuit malfunctions in obesity, this paper found that obese rats had a reduced dopamine response to amphetamine as compared to lean rats fed only chow - figure 4 above demonstrates this suppressed dopamine release from the dorsal striatum.

Return to Neural Reward, Energy Homeostasis, and Addiction-like Compulsive Eating.

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