By Emily Latorraca and Stacey Reiss
To say that obesity is caused by merely consuming too many calories is like saying that the only cause of the American Revolution was the Boston Tea Party.
~ Adelle Davis (American nutritionist and author, 1904-1974)
Click here for the historical background surrounding the controversy.
Epstein, D.H. and Shaham, Y.
Cheesecake-eating rats and the question of food addiction
Nature Neuroscience 13(5): 529-531
Johnson, P.M. and Kenny, P.J.
Nature Neuroscience 13(5): 635-641
Kim, K.S. et al.
J. Biol. Chem. 285(12): 8905-8917
N.B. The article by Epstein and Shaham is a concise summary of the Johnson and Kenny article.
Historical Background Papers
Campfield, L.A. et al.
Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks
Science 269: 546-549
Effects of Parabiosis of Obese with Diabetes and Normal Mice
Diabetologia 9: 294-298
Hetherington, A.W. and Ranson, S.W.
The Relation of Various Hypothalamic Lesions to Adiposity in the Rat
J. Comp. Neur. 76: 475-499
Olds, J. and Milner, P.
Positive Reinforcement Produced by Electrical Stimulation of Septal Area and Other Regions of Rat Brain
J. Comp. Physiol. Psychol. 47: 419-27
Recommended Original Research
Click on the titles of these articles to read about one particular figure and its relevance to our research.
Farooqi, I.S. et al.
Science 317: 1355
Geiger, B.M. et al.
Neuroscience 159: 1193-1199
Huang, X.F. et al.
Behavioural Brain Research 175: 415-419
Stice, E. et al.
The Journal of Neuroscience 30(39): 13105-13109
Zhou, Q.Y. and Palmiter, R.D.
Cell 83: 1197-1209
Recommended Review Articles / Commentaries
Avena, N.M., Rada, P., Hoebel, B.G.
Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake.
Neurosci Biobehav Rev 32(1): 20-39
Heindel, J.J. and vom Saal, F.S.
Role of nutrition and environmental endocrine disrupting chemicals during the perinatal period on the aetiology of obesity
Mol Cell Endocrinol 304(1-2): 90-6
Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene
Eur Psychiatry 15: 79-89
Reduced dopaminergic tone in hypothalamic neural circuits
Eur Jour Pharm 480: 125-131
Volkow, N.D. and Wise, R.A.
Nature Neuroscience 8(5): 555-560
Zheng, H. and Berthoud, H.R.
Current Opinions in Pharmacology 7: 607-612
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